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KMID : 1144120120020020111
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Biomedical Engineering Letters
2012 Volume.2 No. 2 p.111 ~ p.117
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Imaging of activated cortical areas after light and electrical stimulation of the rabbit retina: F-18 FDG PET-guided brain mapping
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Woo Se-Joon
Kim Su-Jin
Zhou Jing Ai
Kim Eui-Tae
Seo Jong-Mo
Park Jung-Hyun
Kim Yu-Kyeong
Lee Jae-Sung
Kim Sung-June
Chung Hum
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Abstract
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Purpose: Using 18F- fluorodeoxyglucose positron emission tomography (FDG PET), we aimed to assess the cortical areas activated by light and electrical stimuli in rabbits and to determine the nature of the electrically evoked visual perception by comparing the 2 activated cortical images.
Methods: Three adult white rabbits were used, and 5 18F-FDG PET scans were performed on 5 different days for each rabbit: a resting image, 2 light stimulation images, and 2 electrical retinal stimulation images by suprachoroidal electrodes of the right and left eyes. A small-animal PET scanner (resolution: 1.18 to 1.45 mm) was used for image acquisition. Activated cortical areas were determined by voxel-wise statistical analysis of the difference between the stimulation and resting PET images, and three-dimensional brain imaging of functional activation was constructed.
Results: After visual and electrical stimulation of the rabbit retina, increased metabolism was found in 2 distinct cerebral cortical areas: (1) the ipsilateral frontal cortex (frontal eye field) and (2) the contralateral occipito-parietal cortex (visual cortex). Cortical areas activated after electrical retinal stimulation were nearly identical to the visually activated cortical areas.
Conclusions: Electrical stimulation of the rabbit retina using suprachoroidal electrodes induced a similar cortical activation response as that induced by light stimulation. Brain PET images obtained from stimulation of the retina with light and electric current increase our understanding of cortical perceptions by both stimuli and can be a useful methodology for retinal prosthesis research.
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KEYWORD
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Retinal prosthesis, Positron emission tomography (PET), Fluorodeoxyglucose (FDG), Visual cortex, Suprachoroidal electrode, Artificial vision
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